Stephen Holgate was born in Manchester, England, in 1947. He received his B.Sc., M.B., B.S., and MD from London University, and D.Sc. (Biochemistry) from Southampton University. He completed a fellowship in rheumatic diseases and immunology at Brigham and Women Hospital at Harvard University. He worked at London, and Salisbury hospitals before joining the faculty of Southampton University and Hospital in 1975. In 1986 he became MRC Clinical Professor of Immunopharmacology at Southampton University and honorary consultant physician at Bournemouth and Southampton University Hospitals. He holds FRCP from London, FRCP from Edinburgh and MB, BS honoris causa from the University of Ferrara in Italy. Professor Holgate is the Joint Founder of Southampton’s full-time Specialist Asthma and Allergy Clinics, Founder and Chairman of the Board of Trustees of the Asthma, Allergy and Inflammation Research (AAIR) Charity at Southampton General Hospital and Board Member of the Prince of Wales Foundation of Integrated Health. He is also Chair of the DEFRA Expert Panel on Air Quality Standards, the “Science in Health Group” and the National Allergy Strategy Group, and member of the Department of Health Committee on the Medical Effects of Air Pollution, and the Royal Commission on Environmental Pollution.
Professor Holgate is one of the leading authorities in the field of allergy, both nationally and internationally. An important area of his research has been to understand the role of air pollutants, such as ozone, and other environmental factors (e.g., diet, common cold viruses and house dust mite allergens) in causing and in worsening allergies and asthma. Other important components of his research include the genesis, inflammatory nature and hereditability of asthma. He has led the discovery of ADAM33 – the first of a number of asthma genes, and is currently studying how this gene affects the causes and clinical course of asthma.
Professor Holgate published over 700 papers and edited several textbooks on asthma and rhinitis. His book Allergy, 3rd edition (co-authored with L. Lichtenstein) was named by the British Medical Association “Book of the Year” for the wealth of information it offers on the diagnosis, treatment, and management of allergic diseases and asthma. In addition to the King Faisal International Prize for Medicine, he received the MRC Dorothy Temple Cross Travel Fellowship; Royal College of Physicians’ Graham Paul Prize for Clinical Research; Scientific Achievements Award from the International Association of Allergy and Clinical Immunology (Stockholm) and WHO Rohne- Poulenc Rorer Award. He is an Honorary Fellow of the Royal Society of Arts; Honorary Fellow of the South African Pulmonology Society and Honorary Member of the Nordic Society of Allergology. He was also honored by numerous invited lectureships and visiting professorships.
Holgate and Anderson’s book “Allergy” third edition was awarded the British Medical Association’s Prize for Best Medical book in 2006.
Professor Stephen Holgate, a UK citizen born in 1947, is the Medical Research Council Clinical Professor of Immunopharmacology at the University of Southampton England, and Honorary Consultant. Physician to hospitals in Southampton and Bournemouth. His work is on asthma as an inflammatory disease. He has demonstrated the role of cytokines released from human mast cells and the role of T cells in prolonging the inflammatory response. Professor Holgate’s research has also included the role of respiratory viral infections in asthma and has shown that fibrosis may occur in some patients. This may be important in deciding whether anti- inflammatory therapy should be prolonged. In addition Professor Holgate has investigated the role of genetic predisposition to allergic diseases.