King Faisal International Prize (KFIP) recognizes excellence in 5 categories: Service to Islam, Islamic Studies, Arabic Language & Literature, Medicine, and Science, since 1979

Professor James F. Gusella

Winner of the  
KFP Prize for  
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Topic: Degenerative Diseases of the Nervous System


Nationality: Canada


James Francis Gusella was born in Otttawa, Ontario (Canada) in 1952. He graduated with a B.Sc. in Biology from the University of Ottawa in 1974 and an M.Sc. in Medical Biophysics from the University of Toronto in 1976. He obtained his Ph.D. (Biology) at (MIT) in 1980 and has been working at Harvard Medical School at Massachusetts General Hospital since then. He is currently the Bullard Professor of Neurogenetics in the Department of Genetics at Harvard Medical School and Director of the Center for Human Genetics Research (CHGR) and its Molecular Neurogenetics Unit at Harvard, as well as the Director of the Harvard Medical School Center for Neurofibromatosis and Allied Disorders, Associate Director of the Harvard Medical School-Partners Healthcare Center for Genetics and Genomics and Associate Member of the Broad Institute of the Massachusetts Institute of Technology and Harvard.

Professor Gusella is one of the most distinguished scholars of medical genetics worldwide. He made significant contributions to knowledge of neurodegenerative disorders in general and Huntington’s disease (HD) in particular. Gusella and his coworkers, research focused for many years on tracking down the precise cause of HD. Using reverse genetics for mapping the gene locus of HD on chromosome 4, they were able to identify the gene locus which encodes for Huntingtin, a protein associated with HD, and to elucidate the detailed structure of that gene. These discoveries galvanized both the neuroscience and human genetics communities and set off a torrent of similar studies on other disorders. Gusella and his group also applied their genetic mapping approach to many other disorders involving the nervous system. His laboratory is currently pursuing collaborative research into the genetic basis of various diseases affecting human behaviour.

Gusella’s contributions were published in more than 500 scientific papers in leading international journals, as well as books and book chapters. He holds several patents, and his accomplishments were recognized by more than 40 prizes and honors, in addition to the King Faisal International Prize for Medicine. These awards include, but are not limited to, the Metropolitan
Life Foundation Award for Medical Research, the National Health Council Award for Medical Research (to the Huntington’s Disease Collaborative Group), the J. Allyn Taylor International Prize in Medicine, the Dana Award for Pioneering Achievement in Health, the Lois Pope LIFE International Research Award, the Neuronal Plasticity Award of the IPSEN Foundation, and the
Robert S. Dow Award for Neuroscience. Professor Gusella is a fellow or member of major scientific societies and editorial boards and has given numerous invited lectures at major universities and scientific institutions worldwide.

Professor Gusella and his associates succeeded in mapping the gene locus for Huntington’s disease (BD) on the human chromosome 4. Ten years later he identified the gene locus which encodes for the protein that he called Huntingtin. This seminal discovery enabled him to lead a major collaborative investigation that has culminated in the unravelling of the detailed structure of the HD gene and the expanded CAG repeats that underlie the neurodegenerative changes that characterise this condition. This work has made possible the prenatal and presymptomatic testing of individuals which, in turn, provides the opportunity for genetic counselling in families with a history of BD. Subsequently Professor Gusella and his team were able to identify the chromosomal localisation of genes involved in two other neurodegenerative conditions, Alzheimer’s disease (on chromosomes 21 and 14) and familial amyotrophic lateral sclerosis (on chromosome 21). He and his team are now developing animal models in which to investigate further HD and other hereditary neurodegenerative conditions. In parallel with this pioneering work Professor Gusella has made an outstanding contribution to the training of large numbers of research workers and his laboratory has acquired a unique international reputation as a focus for neurobiological research. Professor Gusella and his colleagues have published 292 papers as well as 78 reviews, symposium contributions and chapters in books.

More about Awarding this Winner

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